Comparison of Single vs Multiple Doses of Antibiotic Prophylaxis in Reduction Post-Caesarean Section Infection Morbidity


  • Kalsoom Waheed
  • Natasha Bushra SIMS
  • Tayyaba Rashid
  • Aqeela Abbas



Elective cesarean section, Febrile morbidity, postoperative wound infection


Objective: This study aimed to compare single vs multiple doses of antibiotic prophylaxis in patients
undergoing caesarean section to reduce morbidity linked with infection.
Methodology: A quasi-experimental study was conducted in the Department of Obstetrics and
Gynaecology, Services Hospital, Lahore from 07-09-2019 to 06-03-2020 after approval from the ethical
review committee. A total of 240 patients (120 in each group) were included in the study. Group A
received a single dose of antibiotic prophylaxis and Group B was administered multiple doses of
prophylactic antibiotics.
Results: Patients booked in the study had a mean age of 27.93±3.62 and 28.80±3.54 years in group-A
and B, respectively. In group A, the mean gestational age was 39.21±0.70 and in group B, 39.27±0.69
weeks. In group A, 9 patients (7.5%) and in group B, 11 patients (9.2%) were primigravida while 111
patients (92.5%) in group A and 109 patients (90.8%) in group B were multigravida. Febrile morbidity
was found in 8 patients (6.7%) in group-A and 6 patients (5.0%) in group B. (p=0.582). Postoperative
wound infection was observed in 11 patients (9.2%) of the group and 8 patients (6.7%) of group B
Conclusion: The study concluded that there was no statistically significant difference between the
two groups, single and multiple doses, in terms of their effectiveness in reducing infections after a
Caesarean section.
Keywords: Elective caesarean section, Febrile morbidity, postoperative wound infection.



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06-09-2023 — Updated on 17-10-2023


How to Cite

Waheed, K. ., Bushra, N., Rashid, T., & Abbas, A. (2023). Comparison of Single vs Multiple Doses of Antibiotic Prophylaxis in Reduction Post-Caesarean Section Infection Morbidity. MedERA - Journal of CMH LMC and IOD, 5(1). (Original work published September 6, 2023)

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