Comparison of Single vs Multiple Doses of Antibiotic Prophylaxis in Reduction Post-Caesarean Section Infection Morbidity
DOI:
https://doi.org/10.5281/zenodo.8307467Keywords:
Elective cesarean section, Febrile morbidity, postoperative wound infectionAbstract
Abstract
Objective: This study aimed to compare single vs multiple doses of antibiotic prophylaxis in patients
undergoing caesarean section to reduce morbidity linked with infection.
Methodology: A quasi-experimental study was conducted in the Department of Obstetrics and
Gynaecology, Services Hospital, Lahore from 07-09-2019 to 06-03-2020 after approval from the ethical
review committee. A total of 240 patients (120 in each group) were included in the study. Group A
received a single dose of antibiotic prophylaxis and Group B was administered multiple doses of
prophylactic antibiotics.
Results: Patients booked in the study had a mean age of 27.93±3.62 and 28.80±3.54 years in group-A
and B, respectively. In group A, the mean gestational age was 39.21±0.70 and in group B, 39.27±0.69
weeks. In group A, 9 patients (7.5%) and in group B, 11 patients (9.2%) were primigravida while 111
patients (92.5%) in group A and 109 patients (90.8%) in group B were multigravida. Febrile morbidity
was found in 8 patients (6.7%) in group-A and 6 patients (5.0%) in group B. (p=0.582). Postoperative
wound infection was observed in 11 patients (9.2%) of the group and 8 patients (6.7%) of group B
(p=0.473).
Conclusion: The study concluded that there was no statistically significant difference between the
two groups, single and multiple doses, in terms of their effectiveness in reducing infections after a
Caesarean section.
Keywords: Elective caesarean section, Febrile morbidity, postoperative wound infection.
References
References:
Kausar R, Yasmeen L. Elective caesarean sections; short antibiotic prophylaxis versus prolonged antibiotic therapy. Professional Med J Jun 2010;17: 304-307.
Heethal J, Sarala N, Kumar TN, Hemalatha M. Pattern of antmicrobial use in caesarean section in a tertiary care hospital in rural south India. Int J Pharm Biomed Res 2010;1:57-61.
Smail FM, Gyte GML. Routine antibiotics at cesaerean section to reduce infection. Cochrane Data base Syst Rev 2010.
Hussein J, Mavalankar DV, Sharma S, Ambruoso LD. A review of health system infection control measures in developing countries: what can be learned to reduce maternal mortality. Globalization and Health 2011,7:14.
Kamilya G, Seal SL, Mukherji J, Roy H, Hazar A. A randomized control trial comparing two different antibiotic regimens for prophylaxis at caesarean section. J Obstet Gynecol Ind 2012;2:35-8.
Bodner K, Wierrani F, Grunberger W, Bordner AB. A comparison between elective caesarean section and planned vaginal delivery in low risk obstetric population. Arch Gynecol Obstet 2011;283:1193-8.
Flores-Padilla L, González-Pérez GJ, Trejo-Franco J, Vega-López G, Cabrera-Pivaral CE, Campos A, et al. Risk factors in cesarean section. Ginecol Obstet Mex 2008;76:392-7.
Misra A. Impact of the HealthChoice program on cesarean section and vaginal birth after C-section deliveries: a retrospective analysis. Matern Child Health J 2008;12:266-74.
Komura R, Mochida T, Imai H, Shibue C, Tobita T, Baba H. Massive hemorrhage during cesarean section for placenta accrete. Masui 2009;58:215-8.
Nayar R, Sahajanand H. Does anesthetic induction for Cesarean section with a combination of ketamine and thiopentone confer any benefits over thiopentone or ketamine alone? A prospective randomized study. Minerva Anestesiol 2009;75: 185-90.
Patel D. Caesarean section. [online]. [cited 2014 March 2]. Available from: http://www.rcog. org.uk/strat.org.
Chamberlain G. Caesarean section. In: Chamberlain G, Steer P, editors. Turnbull’s obstetrics. 3rd ed. London: Churchill Livingstone, 2001. p.601-17
Sekirime WK, Lule JC. Outcome of cesarean section 118 in asymptomatic HIV-1 infection in Kampala, Uganda. J Obstet Gynaecol Res 2009;35:679-88.
Schmidt S. Use and abuse of cesarean section -- a transatlantic evaluation. J Perinat Med 2009;37: 565-8.
Lemus-Rocha R, García-Gutiérrez LB, BasavilvazoRodríguez MA, Cruz-Avelar A, Peralta-Pedrero ML, Hernández-Valencia M. Incidence of infected surgical wound and prophylaxis with cefotaxime in cesarean section. Ginecol Obstet Mex 2005;73: 537-43.
Bodur H, Caliskan E, Anik Y, Cakiroglu Y, Corakci A. Cranial thromboembolism secondary to patent foramen ovale and deep venous thrombosis after cesarean section. Gynecol Obstet Invest 2008;65: 258-61
Conroy K, Koenig AF, Yu YH, Courtney A, Lee HJ, Norwitz ER. Infectious morbidity after cesarean delivery: 10 strategies to reduce risk. Rev Obstet Gynaecol 2012;5:69-77.
Slobogean GP, O'Brien PJ, Brauer CA: Single-dose versus multiple-dose antibiotic prophylaxis for the surgical treatment of closed fractures. Acta Orthop 2010;81:256-62.
Nisa M, Naz T, Afzal I, Hassan L. Scope of surgical site infection (SSI) in obstertrics and gynaecology. J Postgrad Med Inst 2005;19:438-9.
Amenu D, Belachew T, Araya F. Surgical site infection rate and risk factors among obstetric cases of Jimma University Specialized Hospital, Southwest 126 Ethiopia. Ethiop J Health Sci 2011;21: 91-100.
Satyanarayana V, Prashanth HV, Bhandare B, Kavyashree AN. Study of surgical site infections in abdominal
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