MedERA - Journal of CMH LMC and IOD

Peripheral Neuropathy among Patients with Diabetes Mellitus: Use of Douleur Neuropathic Questionnaire

Misbah Amanat Ali — 2023-01-30

Objective: To find out the prevalence of diabetic peripheral neuropathy in patients with diabetes mellitus. Methodology: It was an observational study conducted on a sample of 150 subjects who were enrolled by a convenient random sampling technique. Patients with a history of diabetes for more than 5 years and of 30-85 years of age from both genders were included. Patients with a history of surgery, frozen shoulder psychological issues, and kidney problems were excluded. Data were collected from Allama Iqbal Memorial Hospital & Islam Central hospital, Sialkot using Douleur neuropathic DN 4 questionnaire, and questions about age, lifestyle, glucose level, hypoesthesia, and gender were added. Data were analyzed by SPSS 20. Results: Out of 150 patients with DM, 49 were males and 101 were females. Active lifestyle was found in 53.33% and 46.67% were physically inactive. Higher glucose levels were found in 53.33% of males and 46.67% of females. In 38 (25.3%) individual's upper limb was involved and in 112 (74.7%) lower limb was involved. Out of 150 subjects, 138 (92%) had a score above 4.0 and thus had peripheral neuropathy. A positive correlation between lifestyle and peripheral neuropathy was found by applying Pearson chi-square and the p-value was 0.000.

Impact of Academic Procrastination on Self-esteem among Dental and Medical Undergraduate Students

Vasiqa Bano — 2023-01-30

Objective: The purpose of current study was to investigate the prevalence of academic procrastination among medical and dental students and examine the relationship between academic procrastination and self-esteem status in this populationT.

Study setting and duration: A cross-sectional study was conducted among 312 medical and dental undergraduates in Army Medical College Rawalpindi and Armed Forces Institute of Dentistry Rawalpindi from February 2022 to April 2022.

Methodology: This cross-sectional study was conducted on 312 students of Army Medical College Rawalpindi. Data were collected through questionnaire using the Rosenberg self-esteem scale and the Procrastination Assessment Scale-Student (PASS).The data collected were analyzed using SPSS software version 24.0.Descriptive tests, t-test, ANOVA, and Pearson’s correlation test were performed.

Results: The results indicated that a weak positive correlation (r = 0.022, P < 0.64) existed between academic procrastination scores and self-esteem scores. The mean difference of self-esteem scores (p=0.59) and academic procrastination scores (p=0.75) among males and females does not prove to be significant. The mean self-esteem score of the MBBS students was higher than BDS students. Similarly, the mean academic procrastination score of BDS students was higher than MBBS students.

Conclusion:The current study concluded that academic procrastination leads to low self-esteem among undergraduate students.

Association of Quality of Life with Depression in Patients with Chronic Low Back Pain

Ameena Amjad — 2023-01-30

Objective: The objectives of this study were to evaluate prevalence of depression and extent of disbility among patients with chronic Low Back Pain and to observe the association between the quality of life and depression in these patients.

Methodology: It was a cross-sectional study. A convenient sampling technique was used for data collection. One hundred and seventy eight patients suffering from chronic low back pain were selected from study population. Data was collected using two questionnaires. For assessing depression, Beck's depression scale was used and for measuring Quality of Life , the Oswestry Disability index was used. SPSS 20 was used for data analysis. A p value of <0.05 was considered statistically significant and qualitative variables were presented as frequencies and percentages.

Results: Seventy-one percent of the patients belonged to female gender. 53.9 % of the LBP patients had moderate disability while 20.8% had severe disability and 2.2% were belonging to the crippled category as measured on Oswestry inventory. The Beck's depression scale revealed that 43.3% of the patients suffered from mild mood disturbance, 10.7% had borderline clinical depression , 13.5% and 1.1% patients suffered from moderate and severe depression respectively. Cross tabulation was done between the Oswestry inventory and beck's depression scale. A significant association (p value =
0.001) was revealed between quality of life and depression in LBPpatients.

Conclusion: Majority of the chronic Lower Back Pain patients suffered from moderate levels of disability and mild mood disturbances while a significant association was found between quality of life and depression in these patients highlighting the need for better pain management and follow up to mitigate these negative impacts of chronic lower back pain.

Efficacy of Phytochemicals of Cassia Angustifolia in Chronic Myeloid Leukaemia – An In-silico Analysis

Faisal Mehmood — 2023-02-23

Objective: To discover the compounds of Cassia having activity against the BCR-ABL fusion protein involved in the pathogenesis of CML and to compare it with previously developed inhibitor, nilotinib using in-silico molecular docking.

Methodology: The 3D structure of Human BCR-ABL fusion protein was obtained from PDB (RSCB). The SMILES and Chemical Structures of the ligands were obtained from PubChem. They were prepared in Mol SDF format by the Chem Bio Draw and then converted to PDBQT format using PyRx tool for generating the atomic coordinates for molecular docking. Molecular docking of Nilotinib, Quercimeritin, and Scutellarein with Human ABL Kinase was performed using Autodock4. The ADMET properties were described using Swiss ADME, a web-based tool.

Results: All the three compounds under study bind and make stable complexes with wild-type BCR ABL with the global energies of -12.46, -16.17kCal/mol and -15.41kCal/mol for Nilotinib Scutellarein and Quercimeritin respectively which means that these compounds can act as selective inhibitors of BCR-ABL fusion protein. Quercimeritin, also form Hydrogen bonds with GLU 286 and Asp 381,

Conclusion: The binding energies of the phytochemicals of Cassia are higher in comparison with Nilotinib which has a binding energy of -12.46kCal/mol which suggests a better inhibitory potential of these compounds. Quercimeritin also forms Hydrogen bonds with Glutamine 286 and Aspartate 381, hence its potential to be a potent inhibitor of the BCR- ABL fusion protein is more promising Nilotinib. Further in vitro and in vivo studies are suggested to elaborate the anti-neoplastic potential of Quercimeritin in CML.

Prevalence of Postpartum Depression and its Risk Factors among Pakistani Females

Nusrat Qamar — 2023-01-30

Background: A severe form of clinical depression is related to pregnancy and childbirth. As a new mom, a lot of challenges are encountered in getting used to life with a newborn including lack of sleep. Hormonal changes and fatigue may lead towards psychological maladjustment towards motherhood. Low socioeconomic status, family system, mode of delivery, ill health of infant may be the reasons behind postpartum depression.

Objective: To study the prevalence of postpartum depression among females.

Method: This Cross sectional study was conducted after ethical approval on a sample of 200 females of reproductive age (20-45years). Participants were selected through convenient random sampling on the basis of predefined eligibility criteria. Data were collected from primary and secondary healthcare facilities of district Sialkot using Edinburg postnatal depression screening tool.

Results: The mean age±Std Dev of the participants was 28.09±5.346 years ranging from 20 to 45. Mean±SD of total score EPDS was found 3.53±5.72 with 87.50% participants with score below 13. Out of 200, 25(12.50%) females were candidates for postpartum depression.

Conclusion: Postpartum depression screening helps recognition of the disorder. Postpartum depression among females of the target population is not negligible.