MedERA - Journal of CMH LMC and IOD 2023-09-06T00:00:00+00:00 Editor-in-Chief Open Journal Systems <p>MedERA-Journal of CMH Lahore Medical College and Institute of Dentistry(JCMHLMC) [<strong>ISSN(p): 2521-0106</strong> ,<strong> ISSN(l): 2789-3081</strong>] is an open-access peer-reviewed biomedical journal that publishes current research related to all the aspects of medical sciences. The acronym <strong>MedERA</strong> stands for <em>Medical and Experimental Research Articles</em>. It is an <strong>HEC-recognized Y Category</strong> biannual (2 isssues per year), <strong>double blind peer reviewed</strong>, broad-spectrum, and open-access journal that is indexed in <strong>Bielefeld Academic Search Engine (BASE), EuroPub, GoogleScholar, Scientific Indexing Services (SIS), Directory of Research Journal Indexing (DRJI), Directory of Open Access Scholarly Resources (ROAD), </strong>and <strong>Advanced Science Index</strong> (<strong>ASI)</strong>. The journal publishes Original Articles, Case-reports, Review Articles, Meta-analyses, Commentaries, Editorial, Innovatory papers, and invited reviews that conforms to its scope and editorial standards. To foster the trend of research among medical students, it has a special 'Students section' that publishes good quality research by the students after a rigorous editorial processing. The Journal uses the standard <strong>Online Journal System (OJS)</strong> for online research submission, processing, review, correspondence and publishing. CMH Lahore Medical College and Institute of Dentistry is the parent body of this Journal.</p> Frequency of Chemotherapy-Induced Myalgia in Cancer Patients using The Visual Analogue Scale 2023-03-14T04:27:19+00:00 Tayyaba Kanwal Amna Mehmood Beenish Khalid Hafsa Hashmi Hina Nadeem Ishrat Parveen <p><strong>Abstract</strong><br /><strong>Objective:</strong> The aim of the study was to find the frequency of chemotherapy-induced myalgia in<br />patients with cancer in Lahore.<br /><strong>Methodology</strong>: This cross-sectional study was conducted over a period of six months after ethical<br />approval from February to July 2021. Using a non-probability convenient sampling technique,<br />seventy eligible patients between 45-55 years of age with cancer were included in this study from<br />both public and private hospital settings on the basis of predefined eligibility criteria. A self-<br />structured questionnaire including a visual analogue pain scale was used for data collection. Data<br />was analyzed using SPSS version 21. The qualitative variables were presented with pie charts and<br />quantitative variables are tabulated with frequencies and percentages.<br /><strong>Results:</strong> Mean age±SD of participants was 53±6.9 years. Out of 70 participants, 90% were females. The<br />significant outcome variables included the presence of myalgia, painful girdle, intensity of pain<br />(visual analogue scale), duration of treatment with the chemotherapy drug, dose of chemotherapy<br />drug and chemotherapy sessions. Chemotherapy-induced myalgia was 94.3% among target cancer<br />patients in Lahore.<br /><strong>Conclusion:</strong> In our study, chemotherapy-induced myalgia is alarmingly high in patients with<br />cancers. The pain is mostly moderate in nature and affects the shoulder region. Measures should be<br />adopted to mitigate the chemotherapy-induced myalgia as it adversely affects the patient's already<br />deteriorating quality of life.<br /><strong>Keywords:</strong> Myalgia, Cancer, Cancer Pain, Palliative care, Chemotherapy.</p> 2023-10-17T00:00:00+00:00 Copyright (c) 2023 Tayyaba Kanwal, Amna Mehmood , Beenish Khalid, Hafsa Hashmi, Hina Nadeem, Ishrat Parveen Clinicopathological Correlation of Leiomyoma undergoing Myomectomy in a Tertiary Care Hospital 2023-06-22T07:38:22+00:00 Javeria Mushtaq Tayyiba Wasim Javeria Zunair Anaab Wasim Ume Ammara Waheed Fiza Arif <p><strong>Abstract</strong><br /><strong>Objective:</strong> To evaluate clinic pathological correlation of Leiomyomas undergoing myomectomy in<br />tertiary care hospital.<br /><strong>Methodology</strong>: This cross-sectional study was conducted at Gynaecology and Obstetrics<br />Department, Services Institute of Medical Sciences Lahore, from June2019 to September 2022 on a<br />sample of 123 eligible patients. After a detailed history investigations and clinical examination, e.g.<br />CBC, blood grouping, fasting blood sugar, ESR, ultrasound scan, laparotomy was performed and the<br />size of uterus, tubal and ovaries condition and total number and location of fibroids we noted. A tubal<br />patency test using methylene blue was performed. Histopathological examination was performed to<br />confirm any endometrial pathology or degenerative process. The data was analysed SPSS 21.0.<br />Categorical variables like demographic profile, clinical characteristics, and location of myoma were<br />presented as frequency and percentages.<br /><strong>Results:</strong> Mean age was 25.23±5.623 years. In the study population, 69.1% were nulliparous. Heavy<br />menstrual bleeding was the commonest symptom, constituting 44.7%, mass in abdomen in 30.1%,<br />infertility in 22% and dysmenorrhea in 3.3% cases. Most common site of leiomyoma was Intramural<br />(51.21%), Subseroal 29.26%, and Submucous 19.51%.<br /><strong>Conclusion:</strong> The study concluded that leiomyoma is one of the most common diseases of<br />reproductive age.<br /><strong>Keywords:</strong> Clinicopathological correlation, leiomyomas, fibroids, uterine fibroids.</p> 2023-10-17T00:00:00+00:00 Copyright (c) 2023 DR.Javeria Mushtaq, Dr. Tayyiba Wasim, Dr. Javeria Zunair, Dr. Anaab Wasim, Dr. Ume Ammara Waheed, Dr. Fiza Arif Awareness of Breast Cancer Risk Factors and Breast Self-Examination amongst Rural Women of Pakistan 2023-07-25T04:36:48+00:00 Asim Raza Saad Qayum Hina Irshad Kinza Shahbir <p><strong>Abstract</strong><br /><strong>Objective:</strong> To assess the awareness of major risk factors of breast cancer and understanding and<br />practice related to breast self-examination among rural women of Pakistan.<br /><strong>Methodology:</strong> 396 rural women were enrolled for this cross-sectional study from the catchment rural<br />areas of district Gujranwala between 15th September 2022 to 30th December 2022. A self-structured<br />and valid questionnaire was used to gather information regarding practice and knowledge related to<br />breast self-examination (BSE) and breast cancer risk factors. In this analysis, Statistical Package for<br />Social Sciences (SPSS) version 20 was used to analyse the data at a 95% confidence interval.<br /><strong>Results:</strong> Average age of 396 rural women was 32.96±11.74 years and 25.25% of females were unaware<br />of breast cancer. Only three out of fifteen risk factors were known by 1/3 of the participant which were<br />family history of breast cancer, obesity and lack of breastfeeding. Out of the total population, the<br />majority (84%) had no idea about breast self-examination (BSE) whereas only 16% know about the<br />process of BSE.<br /><strong>Conclusion:</strong> Most rural women were aware of breast cancer however the awareness level was low for<br />the associated risk factors. More importantly, despite being aware of breast cancer the vast majority<br />(84%) had no knowledge or training of BSE.<br /><strong>Keywords:</strong> Breast self-examination, risk factors, breast cancer.</p> 2023-10-17T00:00:00+00:00 Copyright (c) 2023 Asim Raza, Saad Qayum, Hina Irshad, Kinza Shahbir Association of Interleukin-8 Levels with the Development of Uterine Leiomyomas 2023-07-15T20:34:31+00:00 Masooma Talib Ayesha Javed Mariam Malik Muhammad Farhan Zafar Muhammad Shoaib <p><strong>Abstract</strong><br /><strong>Objective:</strong> To find out the relationship between Uterine Leiomyoma and IL-8 levels.<br /><strong>Methodology:</strong> A cross sectional study was conducted on a sample of 100 females (age ranging from<br />25-50 years) including 50 ultrasound confirmed cases of uterine leiomyomas and 50 healthy controls<br />for a duration of 6 months. Levels of plasma IL-8 were measured by ELISA technique.<br /><strong>Results:</strong> Irregular menstrual cycle was reported in about 44% of cases and 11% of controls. Mean<br />number of fibroids in females was two. 54% of women were found to have small (&lt;2cm) sized fibroids<br />while 46% had large sized fibroids. Out of these 78% were intramural and 22% were sub-serosal type<br />of fibroids. Plasma levels of IL-8 were positively correlated (p=0.001) with Uterine Leiomyomas.<br /><strong>Conclusion:</strong> IL-8 levels are significantly higher in patients with uterine leiomyomas depicting a<br />positive correlation between IL-8 and the development of fibroids. However, further studies are<br />required to better understand the role of IL-8 in the development of fibroids.<br /><strong>Keywords:</strong> Uterine Leiomyoma; IL-8, Risk Factors</p> 2023-10-17T00:00:00+00:00 Copyright (c) 2023 Masooma Talib, Ayesha Javed, Mariam Malik, Muhammad Farhan Zafar, Muhammad Shoaib Comparison of Single vs Multiple Doses of Antibiotic Prophylaxis in Reduction Post-Caesarean Section Infection Morbidity 2023-05-11T15:46:55+00:00 Kalsoom Waheed Natasha Bushra Tayyaba Rashid Aqeela Abbas <p><strong>Abstract</strong><br /><strong>Objective:</strong> This study aimed to compare single vs multiple doses of antibiotic prophylaxis in patients<br />undergoing caesarean section to reduce morbidity linked with infection.<br /><strong>Methodology:</strong> A quasi-experimental study was conducted in the Department of Obstetrics and<br />Gynaecology, Services Hospital, Lahore from 07-09-2019 to 06-03-2020 after approval from the ethical<br />review committee. A total of 240 patients (120 in each group) were included in the study. Group A<br />received a single dose of antibiotic prophylaxis and Group B was administered multiple doses of<br />prophylactic antibiotics.<br /><strong>Results:</strong> Patients booked in the study had a mean age of 27.93±3.62 and 28.80±3.54 years in group-A<br />and B, respectively. In group A, the mean gestational age was 39.21±0.70 and in group B, 39.27±0.69<br />weeks. In group A, 9 patients (7.5%) and in group B, 11 patients (9.2%) were primigravida while 111<br />patients (92.5%) in group A and 109 patients (90.8%) in group B were multigravida. Febrile morbidity<br />was found in 8 patients (6.7%) in group-A and 6 patients (5.0%) in group B. (p=0.582). Postoperative<br />wound infection was observed in 11 patients (9.2%) of the group and 8 patients (6.7%) of group B<br />(p=0.473).<br /><strong>Conclusion:</strong> The study concluded that there was no statistically significant difference between the<br />two groups, single and multiple doses, in terms of their effectiveness in reducing infections after a<br />Caesarean section.<br /><strong>Keywords:</strong> Elective caesarean section, Febrile morbidity, postoperative wound infection.</p> 2023-10-17T00:00:00+00:00 Copyright (c) 2023 kalsoom waheed, Natasha Bushra, tayyaba Rashid, aqeela abbas A Case Report on Pancoast Tumor 2023-07-25T04:57:36+00:00 Um-ul-Baneen Muhammad Shah Hussain Fateema Tanveer Muhammad Ali Lak Fatima Ali Wasay Arshad <p><strong>Abstract</strong><br />To present and discuss a case of Pancoast Tumor: an apical lung neoplasm, and subsequently<br />highlight the clinical importance of chronic and progressive complaints, pertaining to this pathology,<br />in helping to detect it and form an early diagnosis.<br /><strong>Case:</strong> A 55-year-old non-smoker male patient, with a known case of gout and uncontrolled diabetes<br />mellitus, presented to emergency with complaints of severe right-sided pain in the chest, subscapular<br />and axillary regions. His electrocardiogram (ECG) and cardiac enzyme came out to be normal. Chest<br />X-ray showed an opacity in the apex of the right lung. On contrast-enhanced computed tomography<br />(CECT), there were enhancing multi-focal lesions in the apical segment of the right lung making a<br />diagnosis of Pancoast tumor.<br />Even though, it may be missed in the early stages as the tumor cannot be seen on imaging investigations<br />and biopsy is more specific at this time, imaging studies do play a substantial role in diagnosing this<br />tumor. Due to the challenges in diagnosing this rare type of lung neoplasm, it is usually diagnosed<br />when it has locally invaded.<br /><strong>Conclusion:</strong> Awareness regarding clinically important warning signs of Pancoast tumors such as<br />chronic and progressive neck and shoulder pain can help healthcare professionals, most notably but<br />not exclusively, chiropractors, in prompt identification of these signs and symptoms, thus facilitating<br />a timely medical and/or surgical referral and an early diagnosis of this pathology. A thorough<br />examination can assist in early diagnosis and lead to a subsequent decrease in mortality and an<br />improvement in quality of life.<br /><strong>Keywords:</strong> Pancoast syndrome, Neck pain, Lung neoplasms.</p> 2023-10-17T00:00:00+00:00 Copyright (c) 2023 Um-ul-Baneen, Muhammad Shah Hussain, Fateema Tanveer, Muhammad Ali Lak, Fatima Ali , Wasay Arshad