Comparison of Oral Progesterone with Oral Progesterone plus Inj. HCG for the Management of Threatened Miscarriage
Keywords:Threatened Miscarriage, Early pregnancy, Progesterone
Background& Objectives: To compare the efficacy of progesterone alone versus progesterone plus human chorionic gonadotropin for management of threatened miscarriage.
Study design: Randomized controlled trial
Place & duration of study: The study was carried out in department of Obstetrics & Gynecology, CMH Lahore for six months from 12" July 2018 to 12th Jan 2019.
Methods: One hundred females with threatened miscarriage fulfilling inclusion criteria were divided in two groups. In group A, 50 females were given progesterone in oral tablet form plus human chorionic gonadotropin (hCG) as intra-muscular injection, while in group B, 50 females were given (oral only) progesterone till 14 weeks. Females were followed up in OPD on weekly basis till 14 weeks of gestation and efficacy of treatment was compared. Efficacy was defined as successful treatment leading to continuity of pregnancy to second trimester (14 weeks of pregnancy) with no vaginal bleeding and no abdominal discomfort/pain.
Results: The mean age of females in group A and B was 24.10 +3.21 and 26.63 +6.05 years, respectively. The mean gestational age, BMI and parity of females in group A and B were 10.01+2.84 vs 10.98+1.52 weeks, 25.10 + 4.43 Kg/m2 vs 27.95 + 3.61 Kg/m2 and 3.01+0.84 vs 1.98+1.24, respectively. Efficacy was 86% with progesterone plus hCG and 42% with progesterone alone for management of threatened miscarriage and it differs significantly among two groups (P<0.05).
Conclusion: Progesterone plus hCG is more effective than progesterone alone for management of threatened miscarriage.
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