Role of Cassia angustifolia in the Treatment of COVID-19 - In Silico Activity of Emodin against SARS-CoV-2 Spike Protein

Authors

  • Shaista Aslam National Institute of Medical Sciences, Rawalpindi, Pakistan
  • Rana Khurram Aftab Punjab Institute of Cardiology, Lahore, Pakistan
  • Ahmad Tariq Punjab Institute of Cardiology, Lahore, Pakistan
  • Avais Ahmad Continental Medical College, Lahore, Pakistan
  • Mussarrat Ijaz Islamia University Bahawalpur, Pakistan
  • Noor e Hira G. C University, Lahore, Pakistan

DOI:

https://doi.org/10.5281/zenodo.%205558615

Keywords:

COVID-19, Cassia angustifolia, Senna Makki, In Silico

Abstract

Background: Coronavirus epidemic has affected wide pulverization throughout the world. There is plenty of data and falsehood via online media with respect to medications and treatment for it. One of the viral advice nowadays is the use of Cassia Angustifolia (Senna Makki). Methodology: This was an in-silico study to evaluate the efficacy of phytoconstituents of Senna against viral spike protein. Results: After docking several phytoconstituents of Senna using AutoDock 4, Emodin was found to best bind with the viral spike protein. Conclusion: Emodin shows great binding capacity with the SARS-CoronaV-2 spike protein and it has feasible pharmacokinetic properties to be used as a drug. Thus, we can infer that Emodin might be helpful for the management of COVID-19. Additional studies and trials are required to assess their actions.

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Published

29-10-2021 — Updated on 10-11-2021

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How to Cite

Aslam, S., Aftab, R. K., Tariq, A., Ahmad, A., Ijaz, M. ., & e Hira, N. . (2021). Role of Cassia angustifolia in the Treatment of COVID-19 - In Silico Activity of Emodin against SARS-CoV-2 Spike Protein. MedERA - Journal of CMH LMC and IOD, 3(1). https://doi.org/10.5281/zenodo. 5558615 (Original work published October 29, 2021)