Screening for Renal Function Impairment in Patients with Chronic Type II Diabetes Mellitus in a Tertiary Care Hospital of Pakistan

Authors

  • Rafiq Ahmad Siddiqui Assistant Professor, Department of Biochemistry, Services Institute of Medical Sciences, Lahore
  • Shamim Akram Associate Professor, Department of Biochemistry, Rashid Latif Khan University Medical College, Lahore
  • Zoolfishan Imran Assistant Professor, Department of Community Medicine, Rashid Latif Khan University Medical College, Lahore
  • Emaan Fatima MBBS Student( 2022-2027) Agha Khan University, Karachi
  • Muhammad Mustansar Professor, De[artment of Biochemistry, Pak Red Crescent Medical College, Lahore
  • Saadia Liaqat Senior Demonstrator, Department of Anatomy, Services Institute of Medical Sciences, Lahore

DOI:

https://doi.org/10.61982/medera.v5i2.112

Abstract

Objective: The objective of the present study was to detect early biochemical changes, in type II
diabetics, indicating renal function impairment leading to Chronic Kidney Disease (CKD).
Methodology: This study was conducted in the Department of Biochemistry at Shaikh Zayed FPGMI,
Lahore during September 2016 to April 2017. It was a cross-sectional analytical study and was done
through nonprobability convenient sampling The study comprised of 50 diagnosed patients of type
II diabetes mellitus (for the last 10 years) and 50 healthy subjects. Both male and female participants
in equal number between the age of 35-75 were included in the study. Blood glucose level (random),
blood urea, serum creatinine, urinary albumin and urinary creatinine were estimated and albumin to
creatinine ratio (ACR) in mg/g was calculated. eGFR was also calculated using S/creatinine. The lab
values of the study parameters were recorded on the designed proforma after getting proper written
consent from the participants. SPSS 20.0 was used for data entry and analysis.
Results: Mean values of random plasma glucose level, blood urea, serum creatinine, urine albumin,
urine creatinine, ACR and eGFR of patients when compared with those of healthy group showed
significant p-values (≤0.05).
Conclusion: There was a significant difference in renal laboratory parameters between diabetic
patients and healthy controls indicating the presence of CKD. In a developing country like Pakistan
type II diabetes mellitus is an incidental finding due to lack of regular health monitoring and it is very
difficult to determine the exact duration of the disease. Patients of type II DM develop CKD (Chronic
Kidney Disease) due to persistent high plasma glucose levels. Therefore good control of DM and
regular monitoring of renal parameters will be helpful in preventing the development of CKD.
Key Words: Diabetes Mellitus, Nephropathy, Chronic Kidney Disease, Urinary Albumin to
Creatinine ratio.

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Published

17-01-2024

How to Cite

Siddiqui, R. A., Akram, S., Imran, Z., Fatima, E., Mustansar, M., & Liaqat, S. (2024). Screening for Renal Function Impairment in Patients with Chronic Type II Diabetes Mellitus in a Tertiary Care Hospital of Pakistan. MedERA - Journal of CMH LMC and IOD, 5(2). https://doi.org/10.61982/medera.v5i2.112

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